ADMET for medicinal chemists : a practical guide / Absorption, distribution, metabolism, excretion, toxicity for medical chemists [edited by] Katya Tsaioun, Steven A. Kates - Hoboken, N.J. : John Wiley & Sons, c2011 - xx, 498 p. : ill. ; 25 cm

Includes bibliographical references and index

In silico ADME/tox predictions / David Lagorce ... [et al.] -- Absorption and physicochemical properties of the NCE / Jon Selbo and Po-Chang Chiang -- ADME / Martin E. Dowty ... [et al.] -- Pharmacokinetics for medicinal chemists / Leonid (Leo) Kirkovsky and Anup Zutshi -- Cardiac toxicity / Ralf Kettenhofen and Silke Schwengberg -- Genetic toxicity : in vitro approaches for medicinal chemists / Richard M. Walmsley and David Elder -- Hepatic toxicity / Jinghai James Xu and Keith Hoffmaster -- In vivo toxicological considerations / John P. Devine Jr. -- Preclinical candidate nomination and development / Nils Bergenhem -- Fragment-based drug design : considerations for good ADME properties / Haitao Ji

0470484071 (cloth) 0470915099 (eBook) 0470915110 (oBook) 0470922818 (ePub) 9780470484074 (cloth) 9780470915097 (eBook) 9780470915110 (oBook) 9780470922811 (ePub)

2010021925


Drugs--Testing
Drug Design
Drug-Related Side Effects and Adverse Reactions
Pharmaceutical Preparations--chemistry
Pharmacokinetics

RM301.27 / .A36 2011

615/.19

2011 D-707 QV 744 / A238 2011