TY - BOOK AU - Kates,Steven A. AU - Tsaioun,Katya TI - ADMET for medicinal chemists: a practical guide SN - 0470484071 (cloth) AV - RM301.27 .A36 2011 U1 - 615/.19 22 PY - 2011/// CY - Hoboken, N.J. PB - John Wiley & Sons KW - Drugs KW - Testing KW - Drug Design KW - Drug-Related Side Effects and Adverse Reactions KW - Pharmaceutical Preparations KW - chemistry KW - Pharmacokinetics N1 - Includes bibliographical references and index; In silico ADME/tox predictions / David Lagorce ... [et al.] -- Absorption and physicochemical properties of the NCE / Jon Selbo and Po-Chang Chiang -- ADME / Martin E. Dowty ... [et al.] -- Pharmacokinetics for medicinal chemists / Leonid (Leo) Kirkovsky and Anup Zutshi -- Cardiac toxicity / Ralf Kettenhofen and Silke Schwengberg -- Genetic toxicity : in vitro approaches for medicinal chemists / Richard M. Walmsley and David Elder -- Hepatic toxicity / Jinghai James Xu and Keith Hoffmaster -- In vivo toxicological considerations / John P. Devine Jr. -- Preclinical candidate nomination and development / Nils Bergenhem -- Fragment-based drug design : considerations for good ADME properties / Haitao Ji ER -